Mydocalm: analogues and substitutes are cheaper in tablets, ampoules, injections

Today we will talk about analogues of Mydocalm. In the current pharmaceutical market there are necessarily two groups of medications - original and generic (copy drugs, analogues). The muscle relaxant Mydocalm, a well-known and quite popular among users, also has a sufficient range of medicinal substitutes. The original remedy itself effectively copes with pain and discomfort in the muscles due to various arthrosis and osteochondrosis. Significantly reduces muscle tone and spasm in multiple sclerosis and after a stroke, has a powerful analgesic effect, and is an anesthetic drug.

However, in some cases, for one reason or another, it may not be suitable for certain patients. This occurs due to individual intolerance to the components of the drug. The use may result in side effects such as: skin rashes, allergic reactions, urticaria, anaphylactic shock, Quincke's edema. The high cost of Mydocalm may also be a reason to encourage you to look for cheaper analogues that have a larger price range.

Dosage form

Mydocalm is a Hungarian medicine intended to relieve muscle spasms and restore metabolism.

Sold in tablet form, as well as in the form of a solution for injections, sealed in ampoules.

The tablets contain 50 or 150 mg of the active substance - tolperisone. One package includes 30 tablets.

One ampoule contains 1 ml of a medicinal solution, including 100 mg of the active ingredient, and another 2.5 mg of lidocaine, an anesthetic. One package contains 5 ampoules.

Indications for use

The drug is prescribed for the following pathologies:

• changes in bone or muscle tissue, accompanied by spasms;
• cerebral palsy, which is spastic diplegia;
• encephalopathy complicated by muscular dystonia;
• stroke;
• multiple sclerosis;
• obliterating atherosclerosis;
• Raynaud's syndrome;
• myelopathy;
• encephalomyelitis;
• intermittent angioedema;
• negative consequences of muscle surgery.

Tolperisone

Centrally acting muscle relaxant. The decrease in pathologically increased skeletal muscle tone is explained by the ability of tolperisone to suppress spinal polysynaptic reflexes and the inhibitory effect on the caudal part of the reticular formation.

It has central n-anticholinergic properties. Does not have a significant effect on the peripheral parts of the nervous system. It has a weak antispasmodic and vasodilator effect.

Release form and composition: Film-coated tablets, white or almost white, round, biconvex, with a characteristic odor.

1 tab. tolperisone hydrochloride 50 mg. Excipients: microcrystalline cellulose - 72.6 mg, lactose monohydrate (milk sugar) - 45.1 mg, croscarmellose sodium - 7.6 mg, hypromellose - 1.9 mg, citric acid monohydrate - 1.5 mg, magnesium stearate - 1.3 mg.

Film shell composition: hypromellose - 3 mg, macrogol 4000 - 0.75 mg, titanium dioxide - 1.25 mg.

Indications for use

Spinal and cerebral palsy (hypertonicity, muscle spasms, spinal automatism; contracture of the limbs).

Diseases accompanied by dystonia, rigidity, muscle spasm; obliterating diseases of the arteries: obliterating atherosclerosis of the vessels of the extremities, diabetic angiopathy, thromboangiitis obliterans (Buerger's disease), Raynaud's syndrome.

Consequences of disorders of vascular innervation (acrocyanosis, intermittent angioedema). Extrapyramidal disorders (postencephalitic and atherosclerotic parkinsonism).

Postthrombotic disorders of lymph circulation and venous circulation, trophic leg ulcer, spastic infantile paralysis (Little's disease), epilepsy, encephalopathy of vascular origin; hypertonicity in combination with another type of muscle tone disorder.

special instructions

Frequent side effects of the drug are hypersensitivity reactions, which can manifest from mild cutaneous to severe systemic, including anaphylactic shock. Symptoms of an allergic reaction are rash, redness, itching, urticaria, Quincke's edema, shortness of breath, arterial hypotension, tachycardia.

Women with a history of allergic or hypersensitivity reactions to other drugs are at higher risk.

Increased caution should be exercised in cases of known hypersensitivity to lidocaine, as cross-reactions may occur.

Patients should be warned to be alert for any possible hypersensitivity symptoms. If they develop, you should immediately stop taking the drug and consult a doctor. After an episode of hypersensitivity, re-prescription of tolperisone is prohibited.

Influence on the ability to drive vehicles and operate machinery. Use with caution in patients whose activities require increased attention and speed of psychomotor reactions.

Contraindications for use

The medication has a small list of contraindications and is usually well accepted by the body. A muscle relaxant should not be used only if there is intolerance to active substances, including lidocaine. Also, injections of the drug are prohibited for children under 3 years of age.

Pregnant women are not contraindicated in treatment with Mydocalm, but it is extremely undesirable, especially in the first weeks of pregnancy.

Whether or not the expectant mother takes the medication is decided only by a medical specialist in each specific case.

The same applies to patients who are breastfeeding.

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Instructions for use of Mydocalm

The optimal daily dose for an adult patient is 150 mg of the drug.

It is enough to take 1 tablet of 50 mg 3 times a day to get rid of spasms.

But if the spasmodic attacks are intense, the doctor may prescribe the patient a higher dose of medication.

Children are prescribed 1 tablet of 50 mg per day. The tablet can be divided into several doses. If it is difficult for a small child to swallow the medicine, the tablet can be ground into powder. The therapeutic course can last no more than 10 days.

Injections of the drug can be both intramuscular and intravenous.

Injections into the muscle are made twice a day, 100 mg of the drug. Injections into a vein are made once a day, 100 mg of the active substance.

It is impossible to plan a therapeutic course and dosage without consultation with a medical specialist. Only a doctor can prescribe the optimal course of treatment and effective daily dose.

Mydocalm is good because it can be taken without fear with any other medications. Also, the activity of the drug is not inhibited by alcohol, therefore, during treatment with a muscle relaxant, drinking alcoholic beverages is allowed.

Baclofen

A muscle relaxant with a central mechanism of action of a group of chlorophenylbutyric acid derivatives. Reduces increased skeletal muscle tone, mainly caused by damage to the spinal cord. Baclofen inhibits skin reflexes and muscle tone, and slightly reduces the amplitude of tendon reflexes.

The pharmacological effect of the drug may be due to hyperpolarization of ascending nerve fibers and inhibition of both monosynaptic and polysynaptic reflexes at the level of the spinal cord. Baclofen does not affect neuromuscular transmission processes. Since the use of baclofen in high doses can cause depression of central nervous system function, the effect of the drug on centers located supraspinally cannot be ruled out.

After oral administration, baclofen is quickly and completely absorbed into the gastrointestinal tract. Therapeutic concentration is 80–395 ng/ml. The maximum concentration in blood plasma (500–600 ng/ml) is achieved 2–3 hours after oral administration. The concentration is then maintained at 200 ng/ml for 8 hours.

Baclofen penetrates into many tissues, but only a small part of it passes through the BBB. Baclofen penetrates the placental barrier. A minimal amount of the drug passes into breast milk. Baclofen is approximately 30% bound to plasma proteins. About 15% of the administered dose of the drug is metabolized in the liver through deamination.

T½ is 2.5–4 hours. From 70 to 80% of baclofen is excreted in the urine unchanged or in the form of metabolites, the rest is excreted in feces. The drug is almost completely eliminated from the body within 72 hours after administration.

Directions for use and dosage

Inside (better during meals). Recommended doses for adults. The initial dose is 5 mg 3 times a day for 3 days, then on every 4th day of treatment the single dose is increased by 5 mg (dose frequency - 3 times a day) until the optimal dose is reached at 20-25 mg 3 times a day .

Recommended dosage regimen:

• Days 1–3 - 5 mg (1/2 tablet of 10 mg) 3 times a day;
• 4–6 days - 10 mg (1 tablet) 3 times a day;
• 7–9 days - 15 mg (1 1/2 tablets of 10 mg) 3 times a day;
• Days 10–12 - 20 mg (2 tablets of 10 mg) 3 times a day.

In most patients, a therapeutic effect is observed after using the drug at a dose of 30–75 mg/day. If necessary, the dose can be gradually increased. For patients requiring higher doses (daily dose 75–100 mg), it is advisable to prescribe tablets containing 25 mg of baclofen.

The daily dose of the drug should not exceed 100 mg. The duration of treatment depends on the clinical condition of the patient. The drug should not be interrupted suddenly, since in this case hallucinations may occur and spastic conditions may worsen. If it is necessary to discontinue baclofen, its dose is reduced gradually.

In elderly patients, the dose of the drug should be increased with extreme caution, since their risk of adverse reactions is higher.

Recommended doses for children: The usual daily dose of the drug is 0.75–2 mg/kg body weight. Treatment should begin with a dose of 5 mg, taken 2 times a day. Children from 12 months to 2 years are prescribed 10-20 mg/day, 2-6 years - 20-30 mg/day, 6-10 years - 30-60 mg/day.

For children over 10 years of age, the maximum daily dose is 2.5 mg/kg body weight. If necessary, the dose can be carefully increased every 3 days until an optimal therapeutic effect is obtained.

Recommended doses for patients with impaired renal function: For patients with impaired renal function, as well as patients on hemodialysis, the dose of the drug is reduced to 5 mg/day.

Side effects

More often occur after a sudden increase in dose, taking the drug in high doses, or in elderly patients. In most cases, after reducing the dose of the drug, they weaken and disappear. If serious side effects occur, treatment should be stopped.

From the side of the central nervous system: 10–63% - drowsiness; 5–15% - vertigo; 4–12% - nausea; 1–11% - confusion; 4–8% – headache; 2–7% - insomnia; 2–4% - weakness and increased fatigue; rarely - euphoria, increased excitability, depression, hallucinations, paresthesia, muscle pain and weakness, ataxia, dry mouth, exhaustion, tremor, asthenia, depression of the respiratory and cardiovascular system, disorientation in space, dizziness, vomiting, adaptation disorder , night terrors, nystagmus, decreased seizure threshold and development of a convulsive attack (especially in patients with epilepsy).

From the cardiovascular system: 0–9% - arterial hypotension; rarely - dyspnea, tachycardia, chest pain, fainting. From the digestive system: 2–6% - constipation; rarely - anorexia, dysgeusia, abdominal pain, diarrhea, positive test results for the presence of occult blood in the stool.

From the genitourinary system: 2–6% - frequent urge to urinate. Other: visual and taste disturbances, rash, itching, ankle swelling, excessive sweating, weight gain, feeling of nasal congestion, changes in plasma glucose levels and other biochemical parameters. In some patients, exacerbation of spastic conditions was noted (paradoxical reaction to the drug).

special instructions

During treatment with Baclofen, exacerbation of psychotic syndromes, schizophrenia, seizures and the occurrence of a state of disorientation in time and space are possible. In such patients, the drug must be prescribed carefully and under close medical supervision.

The dose of the drug must be reduced gradually over 1–2 weeks, since after sudden discontinuation of treatment, anxiety and confusion, hallucinations, psychosis, mania, paranoia and convulsions may develop, and the severity of spastic symptoms may increase.

Prescribe Baclofen with caution to patients with impaired renal or liver function (the dose is reduced depending on the degree of impairment); elderly patients (there is an increased risk of adverse reactions); patients with epilepsy (careful clinical and EEG monitoring is required, since cases of decreased effectiveness of anticonvulsant treatment and changes in the EEG diagram have been identified).

Patients in whom maintaining an upright body position, balance, or increasing motor amplitude depends on muscle tone; patients receiving antihypertensive treatment (possibility of hypotension); patients with stroke, respiratory dysfunction; patients with increased tone of the bladder sphincter (possible urinary retention).

When treated with Baclofen, the concentration of ALT, ALP or glucose in the blood serum may increase. Constant laboratory monitoring is recommended, especially in patients with impaired liver function and patients with diabetes mellitus.

Baclofen penetrates the placental barrier. Due to the lack of data regarding the use of the drug during pregnancy, Baclofen should be taken only if absolutely necessary. Before prescribing Baclofen, the potential benefits and possible risks for both the mother and the fetus must be carefully weighed. Baclofen is excreted in milk, so breastfeeding is not recommended while taking the drug.

When taking the drug, symptoms may be noted due to its sedative effect and the ability to reduce concentration. In this case, it is not recommended to drive vehicles or work with potentially dangerous mechanisms.

Mydocalm analogues are cheaper (list with prices)

Mydocalm is a popular drug. It is one of the most commonly purchased muscle relaxants. However, pharmacies sell a large number of analogues that cost less than Mydocalm. Substitutes in composition and principle of action, produced by different manufacturers, cost 200 - 500 rubles, and have several forms of release.

Below are listed analogues cheaper than Mydocalm, available in injections and tablets:

• Tolperisone – 280 rubles;
• Sirdalud – 340 rubles;
• Baklosan – 370 rubles;
• Baclofen – 380 rubles;
• Miolgin – 230 rubles;
• Texamen – 240 rubles;
• Vitaxon – 190 rubles;
• Trigamma – 145 rubles;
• Meloxicam – 155 rubles;
• Calmirex – 450 rubles.

Sirdalud or Mydocalm - which is better?

If the question arises of what to replace Mydocalm with, then the most popular analogue is the Swiss drug Sirdalud.

This medication is similar to Mydocalm not in the active substance, but in the principle of its effect on the body.

The active component of Sirdalud is tizanidine. The medicine is sold in tablet form, one tablet contains 2 or 4 mg of tizanidine.

The Swiss analogue has a significant advantage over the original drug. Tizanidine, once in the human body, is not absorbed from the tablet immediately, but gradually, so that the medicine acts evenly throughout the day.

The main effect of tizanidine is inhibition of the transmission of nervous excitation, leading to a weakening of muscle tension. Sirdalud is not only a muscle relaxant, but also an analgesic of moderate activity. The medicine begins to act an hour after administration. The spent active substance leaves the body in 3–4 hours.

Sirdalud is prescribed for the following pathologies:

• osteochondrosis and other diseases of the spinal column, complicated by painful spasms of the spinal muscles;
• pathological changes in bone and joint tissue;
• multiple sclerosis;
• stroke;
• convulsive states of any origin;
• cerebral palsy;
• some diseases of the spinal cord;
• negative consequences of spinal surgery.

It is forbidden to take the medication if:

• liver dysfunction;
• intolerance to the active substance;
• treatment with antidepressants, fluoroquinolone antibiotics, CYP1A2 inhibitors;
• feeding a child with breast milk.

The effect of a muscle relaxant on a developing embryo in the womb has not been studied. Therefore, it is not advisable to take the medicine during pregnancy. Doctors prescribe Sirdalud to pregnant patients only as a last resort, when the need for recovery is more important than the likely risk to the fetus.

Sirdalud gives more side effects than Mydocalm. When taking Swiss medication, the following unpleasant phenomena are possible:

• weakness, powerlessness;
• liver dysfunction;
• nausea;
• drying of the oral mucosa;
• disruption of the digestive tract;
• decreased blood pressure;
• slowing heart rate.

Taking Sirdalud can provoke serious pathological changes in the functioning of the liver. Therefore, during therapy, it is recommended to periodically undergo laboratory tests to check the condition of the liver tissue. The drug also has a negative effect on concentration.

Overdose is accompanied by the following symptoms:

• significant decrease in blood pressure;
• nausea;
• weakness, malaise;
• dizziness;
• respiratory dysfunction.

In case of severe overdose, the patient may fall into a coma.

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Characteristics of the drug

"Mydocalm" is a medicine that helps relieve pain in the muscle area. It is used to relieve pain in skeletal muscles only. By consuming Mydocalm, an inhibitory effect occurs in the human body, excitability decreases, and pain decreases. "Mydocalm" is an anesthetic drug that acts as a local anesthetic.

It is applied for:

1. Vasodilation.
2. Reducing muscle tension.
3. Improves lymphatic blood flow.
4. Treatments for Raynaud's disease.
5. Elimination of trophic ulcers.
6. Decreased tone.
7. Treatment of muscular dystonia.
8. Elimination of spastic paralysis.

Action of the medicine

The active ingredient is tolperisone. This substance is used to treat diseases of the central nervous system, increased tone and spasms.

The drug takes effect thirty minutes after administration. The effect may be earlier, but it is after half an hour that the maximum level of con is observed in the blood.

The drug is completely safe. There is no sedative effect after it. "Mydocalm" is not used in cases of hypersensitivity or intolerance to the active ingredients. The tablets should not be used by children under one year of age. The drug in the form of injection ampoules is prescribed to children at least three months old.

Contraindications:

• Muscular hypotonia.
• Myasthenic syndrome.
• Myasthenia.
• The use of the drug is prohibited for people who are allergic to lidocaine.

Use by pregnant women is a controversial issue. No studies have been conducted on this matter, but if necessary, doctors prescribe Mydocalm in the first twelve weeks of pregnancy. Analogues of the drug are prohibited during the lactation period and pregnancy.

How to use

Before using the drug, you should read the instructions. The brief instructions for Mydocalm (tablets) state that the tablets are taken simultaneously with the process of eating. People over eighteen years of age are prescribed a dosage of 450 mg.

It is divided into three doses and drunk throughout the day. For convenience, the tablet is ground into a powder and added to food. The course of treatment begins with a dose of 50 mg, then the dose is gradually increased to 450 mg.

"Mydocalm-Richter" (injections) is injected into a muscle or vein. An injection into a vein should not exceed a dosage of 200 mg of the drug. This amount is divided into two doses. For injection into a muscle you need 100 mg of the drug. Along with Mydocalm (injections), niflumic acid is used.

Children's dosage:

1. Up to seven years – no more than 5 mg per kilogram of child’s weight.
2. From seven to fifteen – from two to four mg of the drug per kilogram of the child’s weight.

Analogues of the drug

"Mydocalm" is a popular drug. It is preferred by more than twenty percent of the population. But few people know that the price of Mydocalm varies from 200 to 1000 rubles, so it is more advisable to purchase drugs that are cheaper, but have similar properties and indications to Mydocalm. There are positive reviews about the product, praising its effectiveness and quick results.

Analogs of Mydocalm are sold in all pharmacies in the Russian Federation and Ukraine. Their cost ranges from 200 to 500 rubles, depending on the company and country of manufacture, components, and release form.

"Mydocalm" is found in the form of ampoules for injections and tablets. The tablets are called Mydocalm, and the injections are called Mydocalm-Richter. All generics have the same indications, but completely different side effects. No one can guarantee that a Mydocalm substitute will be better than its analogue. But despite this, people do not stop purchasing substitutes for this pharmacological “miracle”.

On the pharmacological market you can buy cheap analogues of mydocalm, but no less effective. Medicines can be roughly divided into two groups. The first includes drugs that are an exact copy in component composition, the second includes drugs with other active substances in the composition, but with a similar therapeutic effect as mydocalm.

How to replace mydocalm? The drugs listed below are analogues of the drug Mydocalm. Analogues mean drugs that have the same international nonproprietary name or ATC code. To replace the drug prescribed to you with an analogue, be sure to consult your doctor!

• Baclofen
• Miolastan
• Miorix
• Myoflex
• Muskomed
• Sirdalud
• Tizalud
• Tizanidine
• Tolperil
• Miaxil
• Midostad
• Tolperil

Toperisone. Popular due to low cost. Release form: capsules and tablets. It is used to eliminate and treat radiculitis, hernias, back injuries, and spasms. Not recommended for use by children under one year of age.

It is prohibited to use during the lactation period. A side effect is the occurrence of an allergic reaction to the use of the drug.

"Sirdalud". Relieves chronic spasticity, helps with acute spasms. Take once a day according to instructions. The dose cannot be increased. The increased dosage is prescribed by the doctor based on the patient’s health condition. Release form: tablets. Used to relieve pain after surgery. Contraindications:

1. Kidney failure.
2. Liver failure.
3. Pregnancy.
4. Lactation period.

If we compare Midakalm and Sirdalud, then the second one is better in terms of effectiveness. This drug can act all day, but Midakalm has to be taken several times a day. Both drugs have the same indications for use. But Midakalm has more extensive side effects and Sirdalud is considered an improved analogue of the first.

"Miolgin." Properties of the product:

• Painkiller.
• Antipyretic.

The composition contains paracetamol, which brings down the temperature. Release form: capsules. Used for headaches, neurological disorders, sprains.

Doctors and pharmacists do not recommend taking the drug to minor children. It is prescribed to this category of the population in exceptional cases. Side effects:

1. Dizziness.
2. Sleep disturbance.
3. Allergy.
4. Vomit.
5. Nausea.

Tizalud (Russia). The active substance tizanidine is similar in properties to tolperisone. Relieves muscle spasms in diseases of the spine and spinal cord, convulsions, and normalizes cerebral circulation. Price per pack of tablets: 30 pcs. 4 mg - 205 rubles, 2 mg - 145 rubles.

Tizanil (Russia). The active ingredient is tizanidine. The drug relieves spasms of skeletal muscles and is a pronounced analgesic. Available in a package of 30 pieces containing 2 mg tizanidine - price 160 rubles. or 20 pcs. with 4 mg in the composition at a price of 224 rubles.

Tizanidin Teva (Israel). The main component in the composition is tizanidine. According to doctors, the medicine has high bioavailability, i.e. ability to assimilate. An effective medicine when the dosage and dosage regimen are correctly selected by the doctor.

Noteworthy is the relatively small list of contraindications and possible complications. The low cost compared to other similar drugs characterizes the drug as one of the best analogues. A package of 30 pieces of 2 mg costs 129 rubles.

Baklosan (Russia). The active ingredient is baclofen. In terms of its therapeutic effects, it is similar to mydocalm and an absolute analogue of baclofen described above in paragraph 6, the characteristics of which completely coincide. The cost of a pack is 50 pieces. 10 mg - 280 rub.

All analogues listed in the list have a number of serious contraindications, most of which differ from mydocalm. Replacing drugs with cheaper ones, as well as a treatment regimen and dosage, can only be prescribed by the attending physician, taking into account the characteristics of the course of the disease and the patient’s condition.

Tolperisone or Mydocalm – what to choose?

Tolperisone is a muscle relaxant that normalizes the condition of nerve fibers and relieves muscle spasms. The medication is based on an active substance with the same name. Sold only in tablet form, not available as a solution for injections.

Tolperisone is an analogue of Mydocalm in terms of its effect on the body. The drug is used for the following pathologies:

• muscle spasms of any origin;
• cerebral palsy, represented by spastic diplegia;
• spinal paralysis;
• epilepsy;
• muscle hypertonicity;
• intermittent angioedema;
• parkinsonism;
• acrocyanosis;
• obliterating atherosclerosis;
• encephalopathy.

Tolperisone should not be taken by children under 18 years of age, breastfeeding women, as well as patients with myasthenia gravis and intolerance to the components of the drug.

When taking Tolperisone, unpleasant side effects may occur:

• intense headaches;
• weakness;
• decreased blood pressure;
• allergic skin reaction.

Tolperil

Centrally acting muscle relaxant. The mechanism of action is due to inhibition of the conduction of impulses of primary afferent fibers and motor neurons as a result of membrane stabilizing and local anesthetic effects, which leads to blocking of spinal mono- and polysynaptic reflexes.

By inhibiting the entry of Ca 2+ into synapses, it secondarily prevents the release of mediators. Inhibits the conduction of excitation along the reticulospinal pathway. Increases peripheral blood flow regardless of the influence of the central nervous system. The weak antispasmodic and antiadrenergic effect of tolperisone may play a role in the development of this effect.

Pharmacokinetics. Bioavailability due to pronounced metabolism is about 20%. Metabolized in the liver and kidneys. The pharmacological activity of the metabolites is unknown. T ½ after intravenous administration is approximately 1.5 hours. It is excreted by the kidneys, 99% in the form of metabolites.

Interaction with other drugs and other types of interactions Co-administration of tolperisone increases blood concentrations of drugs predominantly metabolized by CYP2D6, in particular thioridazine, tolterodine, venlafaxine, atomoxetine, desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine. No significant inhibition or induction of other CYP isoenzymes (2B6, 2C8, 2C9, 2C19, 1A2, 3A4) was detected.

When administered concomitantly with other CYP2D6 substrates and/or other drugs, exposure to tolperisone is not expected to increase due to the variety of metabolic pathways of tolperisone. Tolperisone enhances the effect of niflumic acid, therefore, with simultaneous use, it may be necessary to reduce the dose of the latter, as well as other NSAIDs.

Although tolperisone is a centrally acting drug, the likelihood of developing a sedative effect when used is low. In case of simultaneous administration with other centrally acting muscle relaxants, it is necessary to consider reducing the dose of tolperisone.

Features of application

The drug should not be prescribed to children. The most commonly reported reaction with tolperisone was hypersensitivity reaction. Their severity varies from mild skin reactions to severe systemic reactions, including anaphylactic shock. Symptoms of allergic reactions may include erythema, rash, urticaria, pruritus, angioedema, tachycardia, hypotension, or shortness of breath.

Women with hypersensitivity to other drugs or a history of allergic conditions are at higher risk of allergic reactions when using tolperisone.

Patients should be advised to be aware of the possibility of allergies. Patients should be informed that if allergy symptoms occur, stop taking tolperisone and seek immediate medical attention.

After an episode of hypersensitivity to tolperisone, tolperisone cannot be re-prescribed. The drug contains lidocaine, therefore, in case of known hypersensitivity to lidocaine and other amide local anesthetics, the drug should not be used due to the possibility of cross-allergic reactions.

Use during pregnancy or breastfeeding. There is evidence that tolperisone does not have a teratogenic effect in animals. The use of the drug in the first trimester of pregnancy is contraindicated. The use of the drug in the second and third trimesters of pregnancy is possible when, in the opinion of the doctor, the expected benefit significantly outweighs the potential risk to the fetus/child.

Since it is unknown whether tolperisone passes into breast milk, the use of the drug during breastfeeding is contraindicated.

The ability to influence the reaction rate when driving vehicles or other mechanisms. Considering the possibility of developing dizziness, drowsiness, impaired attention, epilepsy, blurred vision, it should be used with caution when driving vehicles and other mechanisms.

Directions for use and doses

For parenteral administration to adults only, the drug should be administered intramuscularly, 1 ml 2 times a day, or slowly intravenously, 1 ml 1 time a day. The duration of treatment is determined by the doctor depending on the nature of the disease and the effectiveness of treatment. Children. The injection solution should not be used for children.

Overdose. Data on overdose are limited. The drug has a wide therapeutic index; according to a dose of 600 mg, it was administered orally to children and did not cause overdose symptoms.

Irritability was observed when children were given 300-600 mg per day orally. There is evidence that the administration of high doses caused ataxia, tonic-clonic convulsions, difficulty and cessation of breathing.

Treatment: drug withdrawal, symptomatic and supportive therapy. There is no specific antidote.

Adverse reactions

Approximately 50-60% of cases of adverse reactions associated with the use of tolperisone were hypersensitivity reactions. In general, these reactions were not serious and went away on their own. Hypersensitivity reactions that are life-threatening have occurred rarely.

From the blood and lymphatic system: anemia, lymphadenopathy. From the immune system: hypersensitivity reaction, anaphylactic reactions, anaphylactic shock. Mental disorders: insomnia, sleep disturbance, decreased activity, depression, confusion.

From the nervous system: headache, dizziness, drowsiness, impaired attention, tremor, convulsions, hypoesthesia, paresthesia, lethargy. From the senses: blurred vision, tinnitus, vertigo.

From the vascular system: hypotension, skin hyperemia. From the heart: angina pectoris, tachycardia, rapid heartbeat, decreased blood pressure, bradycardia. From the respiratory system: difficulty breathing, nosebleeds, shortness of breath.

From the digestive system: nausea, vomiting, abdominal discomfort, diarrhea, dry oral mucosa, dyspepsia, epigastric pain, constipation, flatulence, mild liver damage.

Skin: allergic dermatitis, hyperhidrosis, itching, urticaria, rash. From the musculoskeletal system: muscle weakness, myalgia, discomfort/pain in the extremities, osteopenia. From the urinary system: enuresis, proteinuria.

General disorders: asthenia, discomfort, increased fatigue, anorexia, feeling of intoxication, feeling of heat, irritability, thirst, polydipsia, discomfort in the chest, changes at the site of drug administration (including redness).

From laboratory parameters: increased concentration of bilirubin in the blood, changes in the activity of liver enzymes, decreased platelet count, leukocytosis, increased concentration of creatinine in the blood.

Meloxicam or Mydocalm – what to buy?

Meloxicam is a non-hormonal anesthetic and anti-inflammatory agent based on the active substance of the same name.

It is considered an analogue of Mydocalm based on the principle of its effect on the body.

Sold in tablet form, as well as in the form of suppositories and solution for injections. If you choose analogs in ampoules that are cheaper than Mydocalm, then Meloxicam is a good option.

Meloxicam is prescribed for the following pathologies:

• arthritis;
• osteochondrosis;
• inflammation of joint tissue;
• Bekhterev's disease.

Do not use the medicine if:

• intolerance to the active component;
• kidney dysfunction;
• peptic ulcer;
• bronchial asthma;
• polyps in the nasal cavity;
• pregnancy and lactation.

It should be noted that doctors often prescribe Meloxicam and Mydocalm to patients in combination for the treatment of certain diseases. Although the drugs are analogues of each other, their combined use does not provoke an increase in side effects.

Inexpensive substitutes in ampoules

In addition to the tablet form of muscle relaxants, there are cheap analogues in ampoules, which allows the medicine to be administered by injection. The advantage of these analogues is the quickly achieved therapeutic effect.

Ambien

Ambene is a combination drug whose action is aimed at relieving inflammation, fever and providing an analgesic effect. The medicine is quickly absorbed into the bloodstream after administration. Ambene is indicated for use if the patient has:

1. Arthritis.
2. Pain syndromes caused by degenerative diseases of the spine.
3. Neuralgia.

Indications for use

The medication is used no more than three times a week, the injection is given daily or every other day. The drug must be administered intramuscularly and slowly. In this case, the patient should be in a horizontal position. The temperature of the administered medication should correspond to the patient's body temperature. If repeated treatment is necessary, an interval of several weeks must be observed between therapeutic courses.

It is possible that some side effects may occur from the nervous and digestive systems, which may include:

1. Stomach pain.
2. Lack of appetite.
3. Nausea and vomiting.
4. Dizziness.
5. Sleep disturbance.
6. Psychosis.

Amelotex

Ampoules are not the only form of this drug: it is also available in the form of gel, tablets and rectal suppositories. The Amelotex solution contained in ampoules is a light yellow liquid containing meloxicam. The medication has an analgesic effect, helps reduce fever and effectively reduces the area of ​​inflammation. Amelotex is administered intramuscularly once a day. The maximum permissible daily dose is 15 mg.

The medicine is indicated for use in the following cases:

• arthritis;
• Bekhterev's disease;
• inflammation of the joints, which are accompanied by pain;
• osteoarthritis.

Indications for administration of Amelotex

A course of Amelotex injections is strictly contraindicated for the following problems:

• any bleeding;
• stomach ulcer;
• bronchial asthma;
• pregnancy.

Arthrozan

The medication is a non-steroidal drug that has an anti-inflammatory effect. Artrosan injections have a short-term effect in treating the symptoms of arthritis, spondylitis, osteoarthritis, relieve pain in the lower back and shoulders, and also help with diseases of the muscular system. The daily dose is 15 mg, and the therapeutic effect after its administration occurs within an hour. The drug should not be used if the patient has:

1. Stomach ulcer.
2. Bleeding.
3. Ulcerative colitis.

Benefits of Artrosan

Artrosan should be prescribed with extreme caution to people with gastrointestinal diseases, congestive heart failure, coronary heart disease, diabetes mellitus and alcoholism. The drug is contraindicated for children, pregnant and breastfeeding women.

Dexamethasone

The use of Dexamethasone in ampoules is most often due to the impossibility of using the tablet form. The drug is prescribed if the patient has:

• severe bronchospasm;
• anaphylactic shock;
• cerebral edema;
• severe dermatosis;
• arthritis;
• blood diseases.

Pharmacological features of Dexamethasone

The introduction of Dexamethasone into a joint is prohibited in the presence of severe bone deformation, instability and bone fractures. The dose should be reduced if the patient suffers from infectious, gastrointestinal and cardiovascular diseases. Use during pregnancy is acceptable if treatment is agreed upon with a doctor.

The average dose of Dexamethasone is up to 6 mg, a single injection every three days. In case of overdose, an increase in blood pressure, the appearance of edema, and impaired consciousness are observed. Undesirable effects of the drug include metabolic failure and heart failure.

Mesipol

Mesipol is a solution for deep intramuscular injection. This is a non-steroidal drug that actively fights inflammation, protects and renews connective tissue.

Mesipol injections can be administered only for the first two days after the start of treatment.

After this period, the patient must be transferred to treatment with a tablet form of the medication. The daily dose is no more than 7-15 mg per day. The drug is indicated for the treatment of arthritis and is actively used to treat ankylosing spondylitis.

Neurobion

The medication contains a complex of useful substances (vitamins and microelements), which not only replenishes vitamin deficiencies in diseases, but also stimulates the launch of natural mechanisms for the restoration of nerve tissue. Indications for taking Neurobion are neurological diseases:

• neuritis;
• neuralgia;
• neuropathic pain;
• diseases of the spine.

Dosage of the drug

Neurobion is not suitable for all age groups of patients: children are not allowed to take the drug. You cannot be treated with Neurobion during pregnancy and breastfeeding.