For various problems with cerebral circulation, pathologies of the cardiovascular system and the central nervous system, there is a need to use nootropics.
One of the popular remedies is Gliatilin .
Compound
The basis of the composition is the chemical compound choline alphoscerate.
The area of action of the component extends to choline receptors in the central nervous system.
To ensure that the product is better absorbed by the body, the active ingredient is supplemented with:
- esithol;
- sodium ethyl parahydroxybenzoate;
- gelatin;
- sodium propyl parahydroxybenzoate;
- sorbitans;
- metahydroxide;
- titanium dioxide, iron.
To produce a liquid form, the active ingredient is supplemented with glycerin and liquid in the form of purified water.
Purchase, storage and analogues of medicines
The price of Gliatilin is quite high - ampoules cost about 700 rubles, capsules - 680.
The drug must be stored in a dark place, the temperature should not exceed +25 degrees. The shelf life of tablets is 3 years, ampoules – 5 years. Sold in pharmacies only by prescription.
What is cheaper?
The most popular inexpensive analogues are:
- Cerepro : available in ampoules and tablets. Contains the same active substance as Gliatilin and is prescribed for the same diseases. Its advantage is the price - it is 2 times lower.
- Cereton : has the same pharmacological action and composition as the previous options. Produced in ampoules and capsules.
- Gleatser : Russian inexpensive solution for injections, which has the same active ingredient.
- Cholitilin : produced in tablet form and used for the same symptoms.
- Noocholin : produced in the form of a solution and can replace Gliatilin injections, but it cannot be used in the acute stage of hemorrhagic stroke.
You cannot change the medicine yourself, since each replacement option has certain features that can be harmful or simply not suitable for a particular person.
Instead of Gliatilin, its cheaper analogues can be used only with the agreement of the attending physician.
Pharmacology
The therapeutic effect with high effectiveness is ensured due to the physical and chemical properties of the constituent chemical compounds.
Among the main ones:
- influence on systemic blood flow by accelerating blood circulation;
- activation of metabolic functions;
- stimulation of the reticular formation;
- restoration of lost functionality in case of various types of injuries (damage to brain tissue).
The nootropic corrects the factors of involutional psychoorganic syndrome.
This process is based on the suppression of cholinergic activity, as a result of which the amount of phospholipids in neuronal membranes changes.
Choline alfoscerate easily passes through the morphological structures of the brain, increasing the concentration of the active component mainly in the tissues of the brain, liver and lungs. Under the influence of metabolic processes, the substance is converted into carbon dioxide, after which it is excreted from the body through the intestines and kidneys.
Why do we need nootropics?
Nootropic drugs are drugs that act on the brain. These medications help:
- improving communication between subcortical structures and the cerebral cortex;
- activation of brain activity and learning ability;
- resistance to external factors;
- improving memory.
Choline Alfoscerate Formula
The human nervous system consists of neuron cells that are connected to each other by synapses - impulses pass through them through chemical transmitters. Acetylcholine is one of the transmitters; it is transmitted through cholinergic synapses.
To enhance these signals, centrally acting cholinomimetics are used (one of them is Gliatilin), which affect signal transmission in the central nervous system.
Price and release forms
The cost of the medicine depends on the form of release and dosage:
- Capsules (400 mg, 14 pcs.) – price in the range 720-780 rub..
- Oral solution (600 mg/7 ml, 10 units) – price 520 rub..
- Injection liquid (1000 mg, 4 ml ampoules, 3 units) – price range 565-630 rub..
You can buy a nootropic drug both in a pharmacy chain and in an online store.
One of the main conditions for dispensing a pharmacological product is the availability of a prescription.
When placing an order through an online pharmacy, you have the option of purchasing the medicine without a prescription.
Indications for use
In medicine, nootropic medicine is used for the following pathologies:
- disturbances of visual memory, speech functions;
- syndromes characterized by a decrease in intelligence, memory and other degenerative damage (when the cause of their development is cerebrovascular insufficiency);
- decreased cognitive activity, dementia.
The drug is highly effective in correcting psycho-emotional states, behavioral disorders, and other central nervous system pathologies.
Gliatilin is included in complex therapy to eliminate the consequences that arise from traumatic brain injuries (in the acute phase), when the patient experiences loss of consciousness, a coma, and focal hemispheric symptoms.
Other uses of the medicine:
- for strokes to relieve acute symptoms;
- for rehabilitation after a stroke (promotes the restoration of physical skills and consciousness).
The neuroprotector is also used in therapy for children.
It is considered justified to use the medicine for the following problems:
- neuroses, nervous tics;
- autism;
- ADHD;
- hydrocephalic syndrome;
- cerebral palsy;
- with mental retardation, mental retardation;
- with birth injuries of the brain;
- during labor hypoxia.
Special patient groups
For older people, the drug is prescribed when problems with mental activity begin: its use helps to stay sane longer.
In some cases, Gliatilin can be prescribed for the treatment of children: according to parents, it is especially effective for emotional disorders, problems with brain activity, and during the recovery period after a head injury.
But children can take medicine only as prescribed by a doctor and in accordance with his recommendations. This is due to the fact that medicine is still not ready to definitively answer the question of the effectiveness, safety and possibility of using Gliatilin for the treatment of children.
The medicine should not be taken if you have allergies or individual intolerance to the components; it also cannot be used by pregnant and nursing mothers.
It is important to note that during medical experiments, no negative effects on fetal development were found when pregnant women took the medicine.
That is, a patient who took the medicine in the first weeks of pregnancy will not need to have an abortion. However, the doctor must carefully monitor the development of the fetus and immediately respond to any negative changes.
If the drug is prescribed to a nursing mother, the child will need to be switched to artificial nutrition.
Instructions for use
The injection liquid is designed to administer medication using a needle via the IV or IM route.
Intravenous injections (droppers) are performed with preliminary dissolution of 1 ampoule of the drug with 50 ml of saline solution.
The speed of liquid movement through the system is 80 drops/min.
- Treatment of acute forms of diseases begins with intramuscular injections. The daily dose is 600-1000 mg. Sometimes it is rational to use intravenous medication (up to 3000 mg).
- As soon as there is a positive trend in the patient’s condition, a switch to tablets is made. This takes on average 5-10 days.
The development of a treatment regimen and determination of dosage is carried out exclusively by medical staff. The doctor also has the right to make adjustments to the treatment process if necessary.
The neuroprotector in capsules is taken orally. Taking time: 40-60 minutes before meals.
The treatment regimen involves taking the medicine 2-3 times, 1 tablet each, for 3-6 months (the duration of the course depends on the etiology of the disease, the intensity of its development, and the patient’s condition).
Instructions for use for children:
- It is better to take the medication in the morning before breakfast;
- You need to take the whole tablet only with purified water (100-150 ml);
- when prescribing intravenous drip infusions, the drug is pre-diluted with saline solution;
- IM injections are given into the muscle tissue (the shoulder or femoral part is most often involved);
- injection time – up to 12-14 hours.
For TBI, it is recommended to use 1 ampoule per day for 1 week. After this, a transition to capsules is made (1 unit twice a day for 2 months).
The duration of therapy for birth trauma/hypoxic encephalopathy is about six months. For 10-12 days, injections are given once a day (1-2 ml). The daily norm for children 1-3 years old can increase to 2-3 ml, for the age group over 3 years old - 4 ml. The next stage of therapy is the use of tablets. Capsules are used according to the following scheme: 1 pc. 2 times a day. After 2-3 months, treatment can be adjusted by a specialist under whose supervision the patient is.
From application practice
Reviews from doctors and patients who have undergone treatment with Gliatilin.
I regularly prescribe Gliatilin to older people with memory problems, and it helps a lot. In most cases, improvement begins within the first weeks of use.
After a treatment course, the results are consistently high: patients feel good, sleep and memory improve. Many even manage to remember events from childhood or youth, although until recently their memory regularly failed them.
Olga Petrovna, neurologist, Samara
For me, Gliatilin is the most optimal medicine; I almost always prescribe only it. Works great, no side effects or intolerances, helps both adults and children.
With children, however, you have to act carefully. Several times the kids had to reduce the dose because the recommended ones were too high for them and instead of calming them, they led to agitation.
Igor, pediatrician, Moscow
My son had a delay in speech development, so I started giving him Gliatilin at the age of 3.
Before this, the neurologist prescribed Neuromultivit, but it did not give any result at all. I gave my son a tablet once a day (unfortunately, it could not be divided or crushed, and therefore I had to tinker with it - my son did not want to swallow it), the course was 2 months. After 3 weeks, the baby began to slowly repeat words, somehow put letters and syllables together, and said “dad” for the first time.
After completing the course, he confused the syllables a little, but he already confidently named what I was pointing at, and he also became much more attentive and assiduous. The doctor warned that it may be necessary to take another course, but so far I am very pleased with my son’s progress.
Anna, Pskov
I bought this drug for a 75-year-old grandmother when she began to have serious memory problems: she forgot to turn off the iron or kettle, and could go out onto the next street and get lost.
Alas, it was impossible for her to hire a nurse, nor was it possible to stay at home, so she had to solve the problem with medications. The doctor first prescribed another medicine, a cheaper one, but warned that it might not help, so they decided to take a good one right away.
After a few weeks, the grandmother could already remain alone and calmly go to the store. I even remembered my granddaughter’s birthday, although before that I might have even forgotten about my own.
Maxim, Orenburg
Side effects
In the course of a study conducted to study the effect of choline alfoscerate on the human body, rare cases of side effects were identified.
At the initial stage of therapy, nausea, mild confusion, and epigastric pain may appear.
The doctor who is seeing the patient is informed about unpleasant symptoms. The specialist will adjust the dose, select an analogue, and make other changes to the treatment course.
Cases of overdose and side effects
Cases of drug overdose are extremely rare, but they do happen. They are accompanied by:
- nausea and stomach pain;
- short-term confused consciousness;
- Sometimes allergic skin rashes, redness or itching are possible.
If suspicious symptoms are detected, you must notify your doctor and adjust the dose. Basically, there is nothing to fear, since the negative effect of the medicine will disappear on its own. No severe cases of drug poisoning were noted.
Patient reviews
Albina:
I came across a lot of information about the drug Gliatilin on the forums, but reviews for children are sparsely presented. I decided to share my experience of using a nootropic, which I gave to my child for neurosis. Therapy lasted 4 months (1 capsule per day). Positive dynamics became noticeable after 10 days.
A month later, the child looked absolutely balanced, despite the not always adequate behavior towards him of his peers. I did not observe any side effects throughout the treatment period.
Victor, 37 years old:
After a TBI at the plant, he underwent serious treatment using several drugs. Gliatilin was prescribed to restore lost physical skills and cognitive processes. After a couple of weeks, I felt the first improvements: irritability disappeared, speech became clear and understandable, and concentration increased. No side effects were observed when using the capsules.
Reviews from neurologists
A. P. Stepanov, work experience 22 years:
Gliatilin shows high effectiveness in therapy after stroke attacks, TBI, and CVD. In combination with other pharmacological agents, it is possible to quickly restore lost functionality and cope with disturbances in the blood circulation of the brain. Long-term use of the drug reduces cognitive deficits.
Features of using the nootropic: due to increased excitability, it is recommended to take it before lunch time to avoid negative effects on healthy sleep. Efficiency increases with course therapy, which involves the use of injections at the initial stage, then capsules.
Tatyana Mikhailovna Kuznetsova, practicing specialist with 12 years of experience:
Gliatilin is an effective neuroprotector, as proven by reviews from adults on forums. The opinions of doctors who use psychotropic drugs in their practice do not disagree with them. A high therapeutic effect is achieved with asthenia, VSD, cerebral palsy, etc.
The availability of different forms of release is also considered convenient, which allows you to achieve the desired result with minimal stress on the liver and kidneys.
Medicinal properties
The effect of the drug Gliatilin is ensured by the properties of its main component. The substance choline alfoscerate is a cholinomimetic, a precursor of acetylcholine.
It has a stimulating effect on cholinergic receptors, largely on central ones. After penetration into the body, under the influence of internal processes, it breaks down into choline and glycerophosphate.
Acts as a substrate in the process of synthesizing acetylcholine and phosphatidylcholine in nerve cell membranes. At the same time, it activates cerebral circulation, metabolic transformations in the central nervous system, and the reticular formation (a section of the brain stem that regulates the activation of the brain cortex).
The substance improves the psycho-emotional state: mood, intellectual activity, ability to concentrate, memory, ability to reproduce and analyze received information. It also enhances learning ability and behavior, eliminates lability of emotions and apathy.
Use in the acute period after traumatic brain injury helps to normalize blood circulation in the brain, bioelectrical activity in the area of injury, and accelerates the disappearance of neurological manifestations.
After penetration of choline alfoscerate into the body, it is absorbed in a significant amount (about 89%) and freely passes through the BBB. It accumulates mainly in the brain (44-46% of the applied dosage), lungs, and liver.
It is excreted from the body mainly through the lungs in the form of carbon dioxide (85%), the remainder is excreted in urine and feces.
The substance does not affect reproductive function and does not have a toxic effect on the body.
Analogues of the drug
Any drug that is developed based on choline alfoscerate is hypothetically suitable for therapy.
In fact, a specialist chooses an analogue taking into account several important factors.
The most effective medications are:
- Cerepro;
- Nooholin Rompharm;
- Delecite;
- Cereton;
- Holitylin;
- Gleazer.
For children, the doctor suggests:
- Anvifen (capsules) – recommended from 3 years of age, active substance – aminophenylbutyric acid;
- Cortexin (in injection ampoules) – can be included in therapy for premature babies;
- Aminalon (in tablets) – the composition contains GABA, used from 1 year;
- Pantogam (in the form of syrup) - the composition is based on hopantenic acid, the drug is suitable for any age;
- Nootropil (various forms) - the composition is developed on the basis of piracetam, used from the age of one.
The selection of an analogue is carried out by a qualified specialist who takes into account the properties of the medicine and its area of influence on the health of a particular patient.
How the drug works, its properties
The principle of action of the medicine is quite simple: it enters the body and is absorbed into the blood, through which it enters the brain. There enzymes act on it, after which the drug is divided into:
- glycerophosphate : enhances metabolic processes in nerve cells, takes part in the synthesis of the cell membrane;
- choline : participates in the synthesis of acetylcholine, helps accelerate the speed of impulse transmission between cells.
The functions of the drug also include:
- improving the transmission of impulses between cells, which has a beneficial effect on the speed of brain function;
- increased blood flow to the brain, which helps it receive additional nutrition;
- the product increases the metabolic rate in nerve cells, helps to obtain more energy;
- helps restore consciousness and normalize it, eliminate some neurological symptoms, so the drug has proven itself effective for head injuries;
- has a positive effect on memory, attention and thinking in cases of cerebral circulation disorders;
- eliminates apathy, reduces causeless irritability, enhances brain activity, helps improve mood, can be used by healthy people.
