Indications for use
Negrustin is used for many diseases and syndromes, such as:
- asthenic syndromes;
- phobias;
- anxiety states;
- depressive states, including manic-depressive psychosis;
- excitation with vivid pain syndromes.
You can also use the drug in case of stress, increased mental stress, when you need to relieve excess tension and nervousness. This medication is very helpful for workaholics who need to take a break from work and improve their psycho-emotional state. Since natural Negrustin can be taken before exams, it will not only calm you down, but also prevent inhibition of the nervous system.
"Negrustin": instructions for use, reviews
Despite the fact that the drug is sold without a prescription, experts recommend taking Negrustin as prescribed by a doctor. Instructions for use: the product is taken orally, mainly during meals. The course must last at least 28 days, the maximum period of treatment is two months. If necessary, the patient is prescribed a second course, however, judging by the reviews of doctors, a single dose of Negrustin helps get rid of neurological disorders.
The drug is available in the form of a red or red-brown solution with a pleasant odor. The bottles contain 50 or 100 ml of product. There is also a solid form of medicine - gelatin capsules. Inside there are active granules that have a specific aroma. Such Negrustin tablets are placed in blisters of 10 pieces. There can be 3, 4, 6 or 10 of them in a package.
The simultaneous use of other drugs with similar effects often causes increased side effects. "Negrustin", an analogue of the drug and almost any other antidepressant drug weaken the effect of many drugs. You must familiarize yourself with their list in advance. The instructions that come with the product contain similar information. The drug affects the ability to control machinery.
Reviews from patients agree that the medicine is easily tolerated, rarely causes side effects, and improves mood and well-being.
Contraindications
Do not use Negrustin for the following conditions:
- the appearance of blisters due to exposure to sunlight;
- lactation period;
- in cases of allergy to St. John's wort preparations;
- increased sensitivity to sunlight after taking St. John's wort in the past.
St. John's wort preparations should not be used in cases of treatment of heart diseases or in combination with other antidepressants without consulting a doctor. If you have heart defects, you should also be as careful as possible, since the drug can cause disturbances in the functioning of the heart and increased blood pressure. Also, you should not use Negrustin in the case of treatment of tuberculosis, since isoniazid may lose its effect from St. John's wort preparations.
For severe depression, Negrustin is not used, since its effect is not so strong, but it can be used in combination with other antidepressants for treatment and after the patient’s condition improves, in order to prevent the re-development of a depressive state.
With prolonged use of drugs based on St. John's wort, arterial hypertension and hypertensive crisis may develop; Also, people who have severe atherosclerosis should not take Negrustin, since increased blood pressure can lead to negative consequences for their health. In such cases, only the doctor should choose the dose, since he can analyze all the pros and cons of the medications for the patient’s health.
The drug is characterized by the following side effects:
- diarrhea or constipation;
- feeling of powerlessness;
- headache;
- pain in the epigastric region;
- Iron-deficiency anemia;
- loss of appetite;
- development of allergies to household allergens.
Very often, when consuming preparations based on St. John's wort, skin disorders develop - severe itching, rashes in the form of small pustules, and other pathological skin processes. They are usually associated with allergic characteristics of the human body. But if skin disorders develop, you should stop using medications.
Negrustin
Name: Negrustin Pharmacological action: Negrustin has anxiolytic, antidepressant activity, and has a sedative effect. It has an effect on the central nervous system and the autonomic nervous system. The natural composition of St. John's wort affects the enzyme monoamine oxidase (types A and B). It will suppress their activity. Thanks to this, the level of neurotransmitters does not fall, as in depressive states, but, on the contrary, increases to optimal levels.
The bioflavonoid composition causes the calming effect of St. John's wort preparations. During therapy with Negrustin, an increase in mood, an improvement in the process of falling asleep, an increase in appetite, and an increase in performance are observed.
Indications for use: Negrustin is prescribed for: - asthenia; - feeling of fear; - hypochondriacal depression; - moderate and mild depression; — manic-depressive states; - anxiety; - excessive excitement due to itchy skin; - excitement during pain syndrome.
Directions for use: Capsules and solution are taken orally. Daily dose – 1 capsule. (1 ml of solution) 3 times. For children 12-16 years old – 1-2 tablets/day. The maximum daily dose is 6 ml of solution (6 capsules). The solution can be used without dilution with water. Both forms of release are taken with meals. The minimum course is 4 weeks, the maximum without a specialist appointment is 2 months.
Side effects: Taking the drug Negrustin may be accompanied by: - eczematous rashes; - itchy skin; — photosensitivity; - urticaria; - stool disorder; — asthenic manifestations; - anorexia; — increased sensitization to household allergens; - anxiety; - dry mouth; - headache; - nausea; - rash; - anaphylaxis; - epigastric pain; - iron deficiency anemia.
Contraindications: Negrustin is not prescribed for: - severe depression; - endogenous depression; - taking MAO inhibitors; - therapy with digoxin, cyclosporine and drugs with which dangerous interactions are possible; - lactation; - photodermatitis; - pregnancy; - indications in children; - hypersensitivity to St. John's wort, the St. John's wort family, auxiliary components of the solution, capsules; - history of photosensitivity to St. John's wort preparations.
Pregnancy: Negrustin is not prescribed during pregnancy.
Interaction with other drugs:
| Drug, group of drugs interactions | Result of pharmacological interaction |
| Indirect anticoagulants | The effectiveness of these anticoagulants decreases |
| Amitriptyline, noamitriptyline | Reduced effect of amitriptyline, noramitriptyline |
| MAO inhibitors | Increased antidepressant activity, increased risk of hypertension (up to hypertensive crises) |
| Fluoxetine, fluvoxamine, sertraline, citalopram, paroxetine | Hemolytic reactions, increased “serotonin syndrome” |
| Tetracyclines | Increased photosensitivity |
| Sulfonamides | Increased photosensitivity |
| Thiazide diuretics | Risk of photosensitivity |
| Quinolones | Increased photosensitizing effect |
| Piroxicam | Increased risk of photosensitivity |
| Narcotic analgesics | Prolongation of the morphine sleep stage |
| Preparations for systemic anesthesia | Extending therapeutic sleep |
| Barbiturates | Shortening sleep |
| Reserpine | Reduced hypotensive effect |
| Cyclosporine | Decrease in plasma concentration of this drug |
| Indinavir | Decrease in plasma concentration and effectiveness of indinavir |
| Ethylestradiol, desogestrel | Risk of breakthrough bleeding |
| Theophylline | Increasing the metabolic rate of this alkaloid |
| Digoxin | Reduced effectiveness of digitalis drug |
| Contraceptive drugs | Decreased contraceptive effectiveness |
Overdose: Cases of overdose of Negrustin have not been recorded. Theoretically, if the dose is exceeded, side effects may increase. After taking high doses, you should limit skin exposure to the sun for about 2 weeks.
Release form: Negrustin is produced in capsule form and as a solution. The packaging is as follows: - 30 caps. / package; — 40 caps. / package; — 60 caps. / package; — 100 caps. / package; — bottle 50 ml; — bottle 0.1 l.
Storage conditions: Storage temperature of Negrustin in capsules, solution – up to 25 degrees Celsius. The shelf life established by the manufacturer is 3 years for capsules and 4 years for solution.
Synonyms: Gelarium hypericum, Deprim, Herbion Hypericum, Deprim forte, Neuroplant, Novoimanin, Doppelhertz Nervotonic, Life 600, St. John's wort extract, Life 900, St. John's wort dry extract, Hypericin, Turinervin.
Composition: 1 capsule of Negrustin contains 0.425 g of dehydrated St. John's wort extract. Auxiliary components: lactose, MCC, calcium dihydrogen phosphate, aerosil, talc, magnesium stearate, gelatin, sodium lauryl sulfate, copper chlorophyll complex, titanium dioxide, iron oxide, purified water.
1 ml of Negrustin solution contains St. John's wort extract 791 mg. Auxiliary components: glycerin, 1,2-propanediol, sorbitol, complex flavor.
Additionally: Reaction speed and attention may be somewhat weakened during Negrustin therapy. This is important for drivers and people engaged in potentially dangerous work to know.
Drinking alcohol and visiting solariums and beaches during treatment are prohibited. The use of external and internal agents that enhance photosensitivity is strictly limited.
1 ml of Negrustin solution corresponds to 0.01 XE.
Attention! The description of the drug " Negrustin " on this page is a simplified and expanded version of the official instructions for use. Before purchasing or using the drug, you should consult your doctor and read the instructions approved by the manufacturer. Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
Overdose
There have been no cases of overdose of this drug. After taking high doses, side effects may increase. Also, after taking high doses, it is worth limiting sun exposure to the skin, as photodermatitis may develop. A significant overdose of St. John's wort can lead to panic attacks, dizziness, amnesia and other memory disorders. Also, very strong allergic reactions, including anaphylaxis, are possible, so it is necessary to consult a doctor before use.
The drug "Negrustin": consumer reviews, side effects and other characteristics
You must remember that this is a drug and, like all medications, it can theoretically cause side effects such as nausea, skin rashes or an allergic reaction.
Drinking alcohol during treatment with this drug is unacceptable. The above-mentioned drug is dispensed without a doctor's prescription. It costs about 200 rubles per package. Many consumers have already appreciated the quality and effectiveness of Negrustin capsules. Many patients left reviews about this product. Most buyers note a tangible effect that is noticeable after just a couple of days of taking this drug - the feeling of anxiety and fear has disappeared, sleep has improved, and mood swings are no longer too sharp. The depression went away irrevocably, and my overall health improved after the course of treatment.
The Negrustin product, the reviews of which from experts are also mostly positive, contains only natural ingredients. It contains the herb St. John's wort and auxiliary components, which are also completely natural and have a positive effect on the nervous system and the body as a whole. From our article you learned all the information about the drug "Negrustin", a review of it, recommendations for use and method of application. Doctors praise it, and consumers are also satisfied with the effect.
