AMITRIPTILINE instructions for use, description of the drug AMITRIPTILINE: contraindications, side effects, dosages, composition - tablets, coating. shell in the directory of medicinal products

Amitriptyline is a drug from the group of antidepressants prescribed for depression, psychosis, emotional and phobic disorders. It has a pronounced sedative and thymoanaleptic effect - treatment leads to activation of the psyche and improvement of mood. Refers to the antidepressants of the “old” generation.

Despite the rapid therapeutic effect, doctors' opinions on this drug in the first line of treatment are divided. Let's look at how amitriptyline works and is used, and the dangers of uncontrolled use and overdose of the drug.

Description of instructions for use of amitriptyline

Amitriptyline is a drug from the group of tricyclic antidepressants. In addition to the main effects, it has an analgesic effect and helps in the treatment of bedwetting.

Amitriptyline is produced by several manufacturers - domestic Veropharm, ALSI Pharma, as well as foreign ones - Grindex, Nycomed, under different trade names:

"Amizol";
"Amirol";
"Saroten retard";
"Triptisol";
"Elivel."

Amitriptyline belongs to the pharmacological group of antidepressants. Its gross formula: C20H23N. The international nonproprietary name (INN) is amitriptyline.

Release forms and composition

Amitriptyline is available in two dosage forms - tablets and solution.

Tablets of 10 and 25 mg for internal use. Packaged in contour packs of 50 and 100 pieces.
Solution 10 mg/ml, ampoules of 2 ml for intravenous and intramuscular administration. There are 10 pieces in a package.

The tablets contain 10 or 25 mg of the active substance - amitriptyline hydrochloride. Additional (inactive) substances - microcrystalline cellulose, talc, lactose monohydrate, silicon dioxide, magnesium stearate, pregelatinized starch.

The composition of the drug "Amitriptyline" in the form of a solution includes 10 mg of the active substance and additionally - hydrochloric (hydrochloric) acid, benzethonium and sodium chloride, dextrose monohydrate, water for infusion.

pharmachologic effect

The drug is a strong antidepressant. The mechanism of action of amitriptyline on the body is an increase in the concentration of norepinephrine in synapses and serotonin in the nervous system (their reabsorption is reduced). With long-term treatment, the functional activity of beta-2 adrenergic and serotonin receptors in the brain decreases. It has a strongly pronounced anticholinergic effect (central and peripheral).

How does amitriptyline work for depression? — improves mood, reduces psychomotor agitation, anxiety, and normalizes sleep. The antidepressant effect of the drug appears 2–3 weeks after the start of use.

In addition to the pronounced antidepressant effect, the medicine has a number of other effects.

Antiulcer associated with blocking histamine receptors in the digestive organs.
Decreased appetite.
Increasing the ability of the bladder to stretch and increasing the tone of its sphincter, based on a decrease in the activity of serotonin and acetylcholine receptors.
If you are planning to undergo general anesthesia, you must warn your doctor about taking this medication, as it reduces blood pressure and body temperature.
Eliminates pain syndrome. When does amitriptyline begin to help with pain? — according to patient reviews, already on the 2nd–3rd day of treatment.
Eliminates nighttime urinary incontinence.

Indications for use

The list of indications is extensive, but the main reason for prescribing amitriptyline is depressive states of various origins.

What does amitriptyline help with?

Depression - involutional, endogenous, neurotic, reactive, drug-induced, against the background of alcohol withdrawal, organic brain damage. Especially those occurring with anxiety and sleep disorders.
Emotional disorders of mixed nature. Amitriptyline may be prescribed for panic attacks.
Psychosis against the background of schizophrenia, alcohol withdrawal.
Behavioral disorders (changes in attention and activity).
Nocturnal enuresis.
Chronic pain syndrome - oncological, rheumatic diseases, postherpetic neuralgia, post-traumatic pain.
Bulimia nervosa.
Migraine prevention.
Ulcerative lesions of the digestive system.

Indications for the use of Amitriptyline tablets and solution are similar.

Directions for use and doses

The therapeutic dose and duration of treatment are prescribed privately. How long can you take amitriptyline? - a course of no more than 8 months.

Use of tablets

Should I take amitriptyline before or after meals? The tablets are taken after meals, without first chewing, to reduce irritation to the stomach.

The instructions for use of Amitriptyline tablets indicate the following recommended dosages.

Treatment of depressive conditions. The initial dose is 25–50 mg at night. Then increase gradually, over 5 days to 200 mg per day, divided into 3 doses. If the therapeutic effect does not occur within 2 weeks, the daily dose is increased to the maximum possible - 300 mg.
Treatment of headaches, migraines, chronic pain syndrome. The therapeutic dose is 12.5–100 mg per day, the average is 25 mg. How to take amitriptyline correctly for headaches and other types of pain? - once, at night.
The dosage of Amitriptyline tablets for other conditions is selected individually.

How to take amitriptyline at night for insomnia? If there is a sleep disorder due to depression, then this does not require changing the standard regimen; the drug is taken as written above.

Application of the solution

The solution is administered intravenously or intramuscularly, slowly. The daily dose is 20–40 mg, divided into 4 injections. They gradually switch to the oral form, that is, tablets.

Use during pregnancy and lactation

The drug belongs to category C of action on the fetus according to the FDA classification (negative effects were found in animal studies). Therefore, the use of amitriptyline during pregnancy is extremely undesirable. It is used only if the expected benefit to the mother outweighs the danger to the fetus.

When the drug is prescribed during lactation, breastfeeding should be stopped for the entire course of treatment.

Use in childhood

Amitriptyline is prescribed to children for the treatment of bedwetting:

tablets - from the age of six;
solution - from twelve.

Rarely prescribed in childhood for the treatment of depressive conditions. In this case, the dose, frequency and duration of treatment are selected individually.

childhood enuresis

How is amitriptyline taken in children with depression? - dosage is as follows:

at the age of 6 to 12 years - 10-30 mg per day or 1-5 mg/kg;
adolescents from 12 years old - up to 100 mg.

For nocturnal enuresis:

children from 6 to 10 years old: 10–20 mg per day at night;
adolescents 11–16 years old - up to 50 mg per day.

Use in old age

In old age, it is mainly prescribed for mild depressive disorders, bulimia nervosa, mixed emotional disorders, psychosis due to schizophrenia and alcohol dependence.

How should older people take amitriptyline? At a dose of 25–100 mg at night, once. After achieving a therapeutic effect, reduce the dose to 10–50 mg per day.

Side effects and complications

Side effects of amitriptyline develop very often and can be so pronounced that they exceed the therapeutic effect of treatment. In this regard, the decision to prescribe is always made carefully, and patients and their loved ones should assess their condition during treatment.

dilated pupils

Side effects associated with anticholinergic action:

blurred vision, dilated pupils, paralysis of accommodation, increased intraocular pressure in people with a narrow angle of the anterior chamber of the eye;
dry mouth;
confusion;
constipation, paralytic ileus;
difficulty urinating.

Side effects from the central nervous system:

fainting conditions;
drowsiness;
high fatigue;
irritability;
memory impairment;
disorientation in space;
restlessness, anxiety;
hallucinations (often in the elderly and those suffering from Parkinson's disease);
psychomotor agitation;
mania, as well as hypomania;
decreased concentration;
sleep disorders;
nightmares;
asthenia;
headache, tremor, increased epileptic seizures, dysarthria, paresthesia, myasthenia gravis, ataxia, extrapyramidal syndrome are noted.

For the cardiovascular system:

tachycardia;
arrhythmia;
orthostatic hypotension;
ECG changes in patients who do not have heart disease;
blood pressure surges;
violation of intraventricular conduction.

From the gastrointestinal tract:

heartburn;
nausea;
stomach pain;
vomit;
hepatitis;
increased appetite;
obesity or weight loss;
change in taste;
stomatitis;
diarrhea;
darkening of the tongue.

From the endocrine system:

swelling of the testicles;
enlargement of the mammary glands in men;
decreased or increased libido;
problems with potency;
increase or decrease in blood sugar;
decreased vasopressin production.

Allergic reactions:

itching;
skin rash, urticaria;
angioedema (Quincke);
photosensitivity.

Other side effects:

noise in ears;
hair loss;
swelling;
increased body temperature;
enlarged lymph nodes;
urinary retention.

special instructions

You need to take precautions seriously and balance the risk of adverse reactions with the benefits of treatment.

The drug has been proven to increase the occurrence of suicidal thoughts and behavior in children, adolescents and people under 24 years of age suffering from depression and mental disorders. Therefore, the prescription of amitriptyline in this category of patients should be justified!
In elderly patients, treatment may provoke the development of drug-induced psychosis at night. After discontinuation of the drug, the condition stabilizes within several days.
In patients suffering from unstable blood pressure, these indicators should be monitored throughout the entire period of treatment. It may decrease or increase even more.
It is recommended to avoid sudden movements - carefully move to a vertical position from a horizontal one, as dizziness and loss of orientation may occur.
The consumption of alcohol and drugs containing ethanol is prohibited for the entire period of treatment!
If therapy with MAO inhibitors was carried out, amitriptyline is prescribed no earlier than 14 days after their discontinuation.
A dose of the drug more than 150 mg per day reduces the threshold for seizure activity and increases the risk of seizures in predisposed people and patients suffering from epilepsy.
With severe depression, the risk of suicide is always high, therefore, at the beginning of treatment, parallel prescription of benzodiazepines or antipsychotics is recommended.
In patients suffering from cyclic affective disorders, manic and hypomanic states may develop during treatment with amitriptyline. In this case, you should reduce the dose or discontinue the drug.
Patients suffering from thyrotoxicosis and also receiving thyroid hormones may develop cardiotoxic effects.
In combination with electroconvulsive therapy, the drug can only be used under medical supervision.
Patients on bed rest may develop paralytic ileus.
If you are undergoing local or general anesthesia, you should definitely tell your doctor about taking amitriptyline.
Perhaps a decrease in tear production and an increase in mucus in the tear fluid. For those who wear contact lenses, this can cause damage to the corneal epithelium.
People taking amitriptyline for a long time have an increased risk of developing tooth decay.
Caution must be exercised when performing potentially hazardous activities that require alertness and quick reaction. It is not recommended to take amitriptyline while driving a car.

Based on possible reactions, the following categories of people should use this medicine with extreme caution:

suffering from alcoholism;
children and adolescents under 14 years of age;
elderly patients;
for diseases such as schizophrenia, bronchial asthma, bipolar disorder, epilepsy, suppression of bone marrow hematopoiesis, heart and vascular diseases, intraocular hypertension, stroke, decreased motor function of the stomach and intestines, liver and kidney failure, thyrotoxicosis, prostate enlargement, urinary retention, hypotension of the bladder.

Contraindications

All of the following contraindications to the use of amitriptyline are absolute! Therefore, when prescribing a drug, the doctor always examines the patient’s medical history.

When is amitriptyline contraindicated? - in the following conditions:

hypersensitivity to the drug;
acute and subacute periods of myocardial infarction;
in combination with MAO inhibitors, as well as 2 weeks before starting their use;
alcohol intoxication;
poisoning with sleeping pills, psychoactive, analgesic drugs;
angle-closure glaucoma;
severe atrioventricular and intraventricular conduction impairment;
lactation period;
galactose intolerance;
glucose-galactose malabsorption;
lactase deficiency;
tablets are contraindicated in children under 6 years of age, and the solution up to 12 years;
pregnancy, especially in the first trimester.

Storage conditions and shelf life

“Amitriptyline” in tablets and solution should be stored in a dry, dark place, at a temperature not exceeding 25 °C. Children and people with mental illness, alcoholism and drug addiction should not have access to medication!

The shelf life of the drug is 3 years.

Amitriptyline and alcohol

Mixing this medicine with alcohol is strictly prohibited! In some cases, amitriptyline is prescribed to relieve withdrawal symptoms in alcoholics after binge drinking, but only strictly in a hospital setting.

What is dangerous about combining amitriptyline with alcohol?

When taken together, a person falls asleep soundly - the hypnotic effect of the drug increases several times. Exceeding the dose of amitriptyline in this case causes disruption of the respiratory system, which can lead to cardiac arrest.
The effect of alcohol increases - the effect of drinking a glass of beer can be the same as the same amount of vodka.
This dangerous combination is used by many people to enhance the sleeping effect of amitriptyline (deliberately but slightly overdosing). Addiction, similar to a drug addiction, develops very quickly. A person stops thinking sensibly, assessing the danger of the situation, and accurately dosing the drug, so every pill taken can be fatal. In case of severe poisoning with amitriptyline and alcohol, the chances of survival tend to zero.
The consequence of regularly combining amitriptyline with a small amount of alcohol is an irreversible change in the human psyche - intelligence decreases, memory deteriorates, and household and professional skills are lost. All organs and systems suffer, especially the liver, kidneys, heart, blood vessels, and brain. All side effects of amitriptyline are fully manifested.
Time should be allowed between taking alcohol and amitriptyline. You can't take it if you have a hangover. Even if consumed one day after taking the tablets, symptoms of poisoning may appear - nausea, vomiting, decreased visual acuity. When can you take amitriptyline after alcohol? - not earlier than in two days!

You cannot combine amitriptyline and alcohol under any circumstances, as it is deadly!

Contraindications

The drug is not approved for use in the presence of the following diseases and characteristics:

myocardial infarction;
individual characteristics (intolerance to the active substance);
angle-closure glaucoma;
poisoning with certain drugs (sleeping pills, analgesics);
taking psychoactive substances;
severe alcohol poisoning;
breastfeeding (any period);
disorder of bone marrow hematopoiesis.

In some cases, Amitriptyline can be taken, but only with caution:

bronchial asthma;
digestive system disorders;
stroke;
dysfunction of the liver, kidneys;
increased pressure inside the eye;
pregnancy (any stages);
epilepsy;
urinary retention.

Amitriptyline addiction

The drug is not classified as a narcotic, as it does not have an intoxicating or stupefying effect and does not cause classical physiological addiction, like opiates. Dependence on amitriptyline is only psychological, having nothing to do with the physical craving for the drug. To understand the nature of addiction, you need to know the principle of action of the drug - natural neurotransmitters do not decay in the body at a normal rate, so they remain unchanged for a long time. The effect of taking amitriptyline is achieved by maintaining a constant concentration of serotonin and other neurotransmitters at a high level.

Is amitriptyline addictive? Like all antidepressants, it can form a certain dependence - with abrupt withdrawal, the symptoms return again. Only in this sense can amitriptyline be considered a drug, since while the drug is taken, the person feels good, and when the course is completed, the condition returns. It happens that patients switch from antidepressants to real drugs. Therefore, in order to eliminate possible harm from amitriptyline, its use is discontinued gradually, over the course of a month.

Withdrawal syndrome

If you abruptly stop taking the drug, especially if it was taken in high doses, amitriptyline withdrawal syndrome may develop. What symptoms will there be?

nausea;
vomit;
headache;
diarrhea;
sleep disorders;
malaise;
nightmares.

Even with gradual withdrawal, motor restlessness, irritability, sleep disturbances, and difficult dreams develop.

How long does amitriptyline withdrawal last? — the condition is observed for a period of time until all the drug is eliminated from the body, that is, 8–14 days. Further manifestations are more psychological in nature.

The scheme for reducing amitriptyline intake is a gradual reduction in the therapeutic dose over the course of a month, starting from ¼ and until complete withdrawal.

Indications for use

"Amitriptyline" is prescribed by a doctor in the presence of depressive conditions associated with the following manifestations:

sleep disorders;
agitation (restlessness);
high level of anxiety;
withdrawal syndrome in alcoholism;
nocturnal enuresis;
emotional instability;
organic lesions of brain tissue.

The product is also used to treat such pathologies;

nocturnal enuresis;
postherpetic neuralgia;
severe pain;
migraine;
bulimia nervosa;
ulcers of the digestive system.

Overdose

A drug overdose is not uncommon, so in most cases the drug is prescribed only to inpatients, under the supervision of a doctor.

Amitriptyline poisoning according to ICD-10 class

sified - T43.

Causes of overdose

Exceeding the dose for a single dose of medication most often occurs in the following cases:

non-compliance with the dose prescribed by the doctor (intentional or accidental excess);
self-administration of medication without a doctor’s prescription;
combination of the drug in a therapeutic dose with alcoholic beverages.

Overdose symptoms

Depending on the amount of amitriptyline taken, there are 3 degrees of overdose - mild, moderate and severe, which without resuscitation measures is fatal in 100% of cases.

Children are most susceptible to acute overdose, even death.

A mild overdose of amitriptyline is expressed by the following symptoms:

dry mouth;
constipation;
lack of urination;
dyspepsia.

Moderate and severe overdose are always serious and require immediate medical attention.

From the central nervous system - increased drowsiness, hallucinations, causeless anxiety, epileptic seizures, increased reflexes, impaired pronunciation, muscle rigidity, confusion, loss of orientation in space, deterioration of concentration, psychomotor agitation, ataxia, stupor, coma.
From the heart and blood vessels - arrhythmia, tachycardia, intracardiac conduction disturbance, heart failure, sharp decrease in blood pressure, shock, cardiac arrest (rare).
Other manifestations are a decrease in the amount of urine, up to its complete absence, hyperthermia, increased sweating, vomiting, shortness of breath, respiratory depression, cyanosis, kidney and liver dysfunction.
At the terminal stages, blood pressure drops, the pupils do not respond to light, reflexes fade, liver failure, heart failure and respiratory arrest develop.

The lethal dose is 1.5 grams of amitriptyline taken at one time. However, for children, a smaller amount is enough.

Treatment of poisoning

At the first signs of an overdose, the following pre-medical measures must be taken.

Call an ambulance.
Give the patient a liter of water to drink and induce vomiting. Repeat this procedure until clean wash water appears.
Take enterosorbents to reduce the absorption of the drug into the blood - Enterosgel, activated carbon, Atoxil, Polysorb MP and others.
If a person loses consciousness, he needs to be turned to his side.

Treatment of amitriptyline poisoning is carried out in intensive care and includes the following therapeutic measures.

Emergency gastric lavage.
Administration of saline solutions to maintain blood pressure, correct acidosis, and water and electrolyte balance.
Taking cholinesterase inhibitors to eliminate anticholinergic manifestations.
Administration of glucocorticoids for a sharp drop in blood pressure.
Prescription of antiarrhythmic drugs for the heart.
24-hour monitoring of the patient with monitoring of blood pressure and heart rate.
In severe cases - resuscitation, anticonvulsant measures, blood transfusion.

Hemodialysis and forced diuresis have not proven effective against amitriptyline overdose.

There is no specific antidote for amitriptyline poisoning.

Consequences of poisoning

A severe overdose can be fatal, even if medical assistance was provided on time. The cause of death is cardiac arrest, respiratory arrest, severe arrhythmia.

The consequences of an amitriptyline overdose remain, even if the person managed to survive:

mental changes, severe depression;
chronic renal and liver failure;
heart rhythm disturbance.

Residual effects are observed throughout life and require constant drug therapy.

Negative patient reviews

Some patients in reviews of Amitriptyline report severe drowsiness in the first days of treatment. Patients experienced lethargy and lethargy, and had to spend most of the day sleeping. However, doctors believe that this gives the body rest. Prolonged sleep helps restore the psyche during depression.

Other negative reviews concern anticholinergic side effects: dry mouth, urinary retention, constipation and tachycardia. This is a significant disadvantage of this drug. Therefore, many patients prefer to take more modern antidepressants. However, the cost of such drugs is much higher.

Interaction with other drugs

Before starting treatment with amitriptyline, you need to tell your doctor about all medications that you take regularly.

It cannot be combined with MAO inhibitors.
Amitriptyline enhances the inhibitory effect on the brain of sedatives, hypnotics, analgesics, anesthesia drugs, antipsychotics and ethanol-containing drugs.
Reduces the effectiveness of anticonvulsants.
May be prescribed in combination with sleeping pills (for example, Sonapax is taken together with amitriptyline). But in this combination, Sonapax increases the anticholinergic activity - that is, it reduces the ability of brain cells to transmit nerve signals.
When combined with other antidepressants, the effects of both drugs are enhanced.
When combined with neuroleptics and anticholinergic drugs, body temperature may increase and paralytic intestinal obstruction may develop.
Amitriptyline enhances the hypertensive effects of catecholamines and adrenergic stimulants, increasing the risk of tachycardia, cardiac arrhythmias, and severe arterial hypertension.
May reduce the antihypertensive effect of guanethidine and similar drugs.
In combination with coumarin or indanedione derivatives, the anticoagulant activity of the latter may increase.
In combination with cimetidine, the concentration of amitriptyline in the blood plasma increases, which increases the likelihood of developing toxic effects.
Inducers of microsomal liver enzymes (carbamazepine and other barbiturates) reduce the concentration of amitriptyline.
Quinidine reduces the metabolism of amitriptyline.
Estrogen-containing hormonal agents increase the bioavailability of amitriptyline.
In combination with disulfiram and acetaldehyde dehydrogenase inhibitors, delirium may develop.
Amitriptyline can increase depression that appears while taking glucocorticoids.
In combination with drugs for the treatment of thyrotoxicosis, the risk of developing agranulocytosis increases.
Combinations with nootropics lead to a weakening of the effect of these drugs and increase the likelihood of side effects.
Caution should be used when combined with digitalis and baclofen preparations.
Amitriptyline is well compatible with antibiotics and antiviral drugs (for example, Acyclovir). Can be combined as prescribed by your doctor.

Treatment of depression with Dopamine

A normal level of dopamine makes a person satisfied with life and joyful. Lack of the hormone leads to depression. Normalization of hormone levels is possible through:

Doing physical exercises.
Refusal of alcohol.
Limitations on coffee consumption.
Limit the use of caffeine-containing products.

Dopamine - the hormone of happiness

Drug increases in dopamine levels for depression are prescribed against the background of the risk of complications caused by a deficiency of this hormone. The patient is prescribed to take Phenylalaline, Tyrosine, Ginkgo Biloba.

The main component of Phenylalaline is a specific amino acid that converts tyrosine, and then processes it into dopamine. If hormone secretion is disrupted, this drug is indispensable. Ginkgo Biloba helps normalize blood circulation. Taking it increases the concentration of oxygen in the organs.

Worth seeing: How to cope with depression after a missed pregnancy?

Tyrosine has a direct effect on hormone production. The highest percentage of tyrosine is found in vegetables and fruits. A person is recommended to eat more greens, beets, apples, and protein foods. It is advisable to replace black tea with herbal or ginseng decoction.

Answers to frequently asked questions

Here we will answer popular questions based on search queries that relate to the specifics of using amitriptyline and its combination with other drugs not listed in the official instructions.

Is Amitriptyline available with a prescription or not? Terms of sale in pharmacies - only with a doctor's prescription.
What is the compatibility of amitriptyline and Donormil, is it possible to combine these drugs? This combination is practiced by doctors - amitriptyline will enhance the effect of Donormil. But medications are taken at different times of the day and strictly in a hospital under the supervision of a doctor.
What is the compatibility of amitriptyline and Phenibut? Since Phenibut is a nootropic, when combined with amitriptyline, the therapeutic effect of both drugs is reduced, and the likelihood of side effects increases. This combination should be discussed with your doctor.
Is amitriptyline compatible with Corvalol? The drugs do not antagonize, but Corvalol contains phenobarbital, which can enhance the effect of amitriptyline.
Is carbamazepine (Zeptol, Carbalepsin retard, Tegretol, Finlepsin) compatible with amitriptyline? The drugs can be prescribed together, but it should be remembered that there may be an increased inhibitory effect on the central nervous system, a decrease in the anticonvulsant effectiveness of carbamazepine and a decrease in the concentration of amitriptyline in the blood.
Is it possible to take amitriptyline together with phenazepam? Such medications can be prescribed in parallel only in short courses to speed up the relief of symptoms and reduce the side effects of the antidepressant.
Is amitriptyline and cinnarizine compatible? Prescription is possible, but under the supervision of a doctor, since this combination will enhance the effect of the antidepressant.
What is the compatibility of fluoxetine and amitriptyline, can they be combined? Fluoxetine is also an antidepressant, but from a different group and with a different mechanism of action. The combination is possible using minimal therapeutic doses of drugs and only as prescribed by a doctor, but it is dangerous due to the development of side effects.
Is Velafax compatible with amitriptyline? This is also an antidepressant, the mechanism of action of which is different. A combination of them is possible, but taking the drugs is divided by time - Velafax in the morning, and amitriptyline in the evening in a smaller dose, and the body’s reaction must be monitored in order to exclude an inhibitory effect on the central nervous system.
Is amitriptyline compatible with piracetam? Nootropics are not recommended to be combined with antidepressants due to the difference in their effects - stimulating versus sedative. The effectiveness of the two drugs may decrease and the risk of side effects may increase. If such a combination is prescribed by a doctor, then it is advisable to divide the intake of tablets over time.
Is it possible to take amitriptyline and Paxil at the same time? These are two antidepressants from different groups. This combination is used, but should not be taken on its own, as there is a risk of enhancing the effects of both of them.
What is the compatibility between amitriptyline and Eglonil? It is a neuroleptic with antipsychotic effects, so when used together there is a risk of enhancing the depressant effect on the central nervous system. If such a combination is practiced, the drugs are prescribed at different times.
Can escitalopram be taken with amitriptyline? The combination of two antidepressants is not always appropriate. Sometimes this combination is practiced for severe depression, but the best therapeutic effect develops when combining an antidepressant and a tranquilizer.
Is it possible to take Afobazole and amitriptyline together? The drugs are compatible since Afobazol is a tranquilizer and is often prescribed in combination with antidepressants. But against the background of stronger amitriptyline, the effect of Afobazole may be lost, so the selection of therapeutic doses should be done exclusively by a doctor.
Is it possible to take amitriptyline and Atarax together? This is a drug from the group of tranquilizers, so it is likely to be combined with amitriptyline for depressive conditions. But it is necessary to take them at different times.
Are there drugs similar to amitriptyline that can be bought without a prescription? There are mild over-the-counter medications whose effects can be classified as antidepressants - “Persen”, “Novo-passit”, “Deprim”, “Azafen” and others. But selling medications without a prescription does not mean that you can prescribe treatment yourself!
Is it possible to take amitriptyline and Finlepsin together? The medicine is used to treat epilepsy, as well as neuralgia and pain syndrome, so it is likely that the inhibitory effect of amitriptyline on the central nervous system will increase or its concentration in the blood will decrease.
Can amitriptyline be taken as a sleeping pill? When insomnia is not associated with depression, the drug is not indicated.
If you take amitriptyline often, what will be the consequences? Long-term continuous treatment is always associated with a high risk of side effects. Therapy with such a serious drug should be carried out only under the supervision of a doctor and in adequate doses.
Is it possible to give amitriptyline to a drunk person? No, it is absolutely incompatible with alcohol!
Does amitriptyline have a cumulative effect or not? Yes, the therapeutic effect of this medicine is cumulative and occurs completely after 2–3 weeks.
Why do people get fat from amitriptyline? One of its side effects is increased appetite. Sometimes this leads to weight gain.
Does amitriptyline increase or decrease blood pressure? The drug can both reduce and increase it. Jumps in indicators can be observed throughout the day.
How to get rid of weakness after taking amitriptyline? Getting used to the drug lasts for 7–14 days. If the condition does not improve, the dose should be reconsidered or the medicine replaced with another one.
How long does amitriptyline last? The active substance enters the blood within 30 minutes after administration and remains there for approximately 7–10 hours (maximum 28 hours). One dose of the drug lasts approximately this amount.
How long does it take for amitriptyline to leave the body? Its complete elimination occurs 7–14 days after the end of administration.
Which doctor prescribes amitriptyline? - psychiatrist.
How long can you take amitriptyline without interruption? The course of treatment is a maximum of 8 months.

Amitriptyline is a potent drug that belongs to the “old” generation of antidepressants. Its severe side effects sometimes outweigh the benefits of treatment. Therefore, the decision to take it should only be made by a doctor. Self-prescribing such a medicine is life-threatening!