Comparison of the effectiveness of Phenazepam and Oxazepam
Phenazepam is more effective than Oxazepam - this means that the ability of the drug substance to provide the maximum possible effect is different.
For example, if the therapeutic effect of Phenazepam is more pronounced, then with Oxazepam it is impossible to achieve this effect even in large doses.
Also, the speed of therapy is an indicator of the speed of the therapeutic action; Phenazepam and Oxazepam are also different, as is bioavailability - the amount of a drug reaching the site of its action in the body. The higher the bioavailability, the less it will be lost during absorption and use by the body.
Comparison of the safety of Phenazepam and Oxazepam
The safety of a drug includes many factors.
At the same time, for Phenazepam it is quite similar to Oxazepam. It is important where the drug is metabolized: drugs are excreted from the body either unchanged or in the form of products of their biochemical transformations. Metabolism occurs spontaneously, but most often involves major organs such as the liver, kidneys, lungs, skin, brain and others. When assessing the metabolism of Phenazepam, as well as Oxazepam, we look at which organ is the metabolizing organ and how critical the effect on it is.
The risk-benefit ratio is when the prescription of a drug is undesirable, but justified under certain conditions and circumstances, with the obligatory observance of caution in use. At the same time, Phenazepam does not have any risks when used, just like Oxazepam.
Also, when calculating safety, it is taken into account whether only allergic reactions occur or possible dysfunction of the main organs. In other matters, as well as the reversibility of the consequences of using Phenazepam and Oxazepam.
About Clonazepam
Clonazepam belongs to the group of benzodiazepines and is an analogue of Phenazepam, but unlike it, it is used in most cases for the treatment of epileptic seizures and convulsions, due to the high efficiency of the muscle relaxant effect. What else is this drug used for?
Indications for use
- epilepsy
- seizures, nervous tics
- Lundborg disease
- feeling of fear, various phobias
- emotional instability
- depression
- psychoses
- sleep disorder
Comparison of addiction between Phenazepam and Oxazepam
Like safety, addiction also involves many factors that must be considered when evaluating a drug.
So, the totality of the values of such parameters as “o syndrome” for Phenazepam is quite similar to the similar values for Oxazepam. Withdrawal syndrome is a pathological condition that occurs after the cessation of intake of addictive or dependent substances into the body. And resistance is understood as initial immunity to a drug; in this it differs from addiction, when immunity to a drug develops over a certain period of time. The presence of resistance can only be stated if an attempt has been made to increase the dose of the drug to the maximum possible. At the same time, Phenazepam has a fairly low “syndrome” value, just like Oxazepam.
Elzepam or Phenazepam: which is better, the difference between the drugs
The main active ingredient in Phenazepam is bromodihydrochlorophenylbenzodiazepine. This is a white or slightly creamy powder, thanks to which it is possible to achieve muscle relaxant, hypnotic, anticonvulsant, anti-anxiety and a number of other effects.
In addition to the main active ingredient, the drug Phenazepam contains a number of excipients that provide the necessary consistency and preservation of properties. The tablets may contain potato starch, lactose, talc and a number of other substances.
The injection solution contains povidone, glycerol, sodium disulfite, etc.
Precautionary measures
It is contraindicated during work for transport drivers and other persons performing work that requires quick reactions, precise movements and concentration, therefore during treatment you should refrain from such work.
The frequency and nature of side effects depend on individual sensitivity, dose and duration of treatment. When you reduce the dose or stop taking Fesipam, the side effects disappear.
The drug enhances the effect of alcohol, so drinking alcohol during treatment with Fesipam is not recommended.
Dosage, release forms and manufacturers
Phenazepam is available in two main forms: tablets and injection solutions. Each ampoule of injection solution contains 1 mg of active substance per 1 ml of liquid.
Important! The medication is available only in ampoules of 1 ml. There is no alternative form of release of the injection solution.
Tablets on pharmacy shelves can be found in three dosages: 0.5 mg, 1 mg or 2.5 mg. It is worth remembering that the selection of the optimal dose is made by the attending physician.
There are many pharmaceutical companies producing Phenazepam. Among them:
- Valens;
- Moskhimfarmpreparaty im. Semashko;
- Akrikhin et al.
There are also many foreign companies producing the drug under other trade names.
Possible complications
Elderly patients often complain of a feeling of fatigue, weakness, dizziness, drowsiness, slow reactions, poor coordination, and worsening mood.
In addition, when taking the drug, asthenia and dysarthria may begin. In rare cases, paradoxical reactions appear.
These include hallucinations, muscle spasms, sleep disturbances, outbursts of aggression, and the appearance of suicidal tendencies.
Problems may also arise from the gastrointestinal tract. In some cases, when taking Phenazepam, nausea, dry mouth, heartburn may occur, vomiting may occur, constipation or diarrhea may occur.
The drug also affects the reproductive system. Libido may increase or decrease, and dysmenorrhea may appear. The occurrence of allergic reactions in the form of rashes and skin itching cannot be ruled out. It is also worth remembering that pills are addictive and drug dependence appears. While taking them, blood pressure may decrease and tachycardia may appear.
Indications, contraindications and side effects
Today, doctors prescribe Phenazepam for strictly defined indications. Among them:
- neurotic and neurosis-like states, mental disorders accompanied by anxiety, increased irritability, attacks of fear, lability of emotions;
- reactive type psychoses;
- hypochondriacal-synesopathic syndrome;
- various sleep disorders, autonomic dysfunctions;
- to combat acute attacks of fear, emotional stress;
- as an anticonvulsant drug to combat temporal and myoclonic forms of epilepsy;
- in neurology to get rid of tics, hyperkinesis, autonomic lability, etc.
Phenazepam is not used for myasthenia gravis, poisoning with a number of tranquilizers, antipsychotics, sleeping pills, and narcotic analgesics. A serious contraindication is during pregnancy and lactation, as well as disorders of the liver and kidneys.
Pharmacodynamics
Tranquesipam is a tranquilizer, a benzodiazepine drug with anxiolytic, sedative, hypnotic, anticonvulsant and central muscle relaxant effects.
The mechanism of its action is associated with increased inhibition of the effect of gamma-aminobutyric acid on the transmission of nerve impulses, inhibition of polysynaptic spinal reflexes, stimulation of binding sites with benzodiazepines, which are located in the allosteric center of postsynaptic gamma-aminobutyric acid receptors.
Tranquesipam helps reduce the excitability of subcortical brain structures such as the limbic system, hypothalamus, and thalamus.
A manifestation of the anxiolytic effect is a decrease in emotional stress, a weakening of feelings of fear, anxiety, and restlessness.
The influence of the active substance on the reticular formation of the brain stem and nonspecific nuclei of the thalamus causes the sedative effect of Tranquesipam, which reduces the manifestations of symptoms of neurotic origin.
The hypnotic effect is associated with inhibition of the cells of the reticular formation of the brain stem, as a result of which the impact of vegetative, emotional, and motor stimuli on the mechanism of falling asleep is reduced.
The anticonvulsant effect is associated with increased presynaptic inhibition, as a result of which only the propagation of the convulsive impulse is suppressed, while the state of excitation in the focus itself is preserved.
The central muscle relaxant effect of Tranquesipam becomes possible mainly due to the inhibition of polysynaptic spinal reflexes and, to a lesser extent, the inhibition of monosynaptic spinal reflexes. In addition, direct inhibition of motor nerves and muscle contractility is possible.
Pharmacokinetics
After taking Tranquesipam tablets orally, the drug is rapidly absorbed from the gastrointestinal tract, which allows it to reach maximum concentration in the blood plasma within 1–2 hours. The active substance is characterized by a wide distribution in the body. Metabolism of bromodihydrochlorophenylbenzodiazepine occurs in the liver.
The half-life is 6–18 hours.
It is excreted from the body in the form of metabolites mainly through the kidneys.
Therapeutic effect
Phenazepam can be used for various anxiety disorders due to the following effects of the drug:
- anxiolytic i.e. anti-anxiety, achieved by inhibiting the area of the brain responsible for emotions;
- sedative, capable of having a stabilizing effect on the patient’s emotional state, reducing his susceptibility to various external situations;
- a sleeping pill that makes it easier to fall asleep, reduces the frequency of awakenings at night, and generally improves the quality of sleep;
- muscle relaxant i.e. relaxes muscles by inhibiting nerve conduction in general;
- anticonvulsant i.e. allowing to stop a convulsion or epileptic seizure.
Differences
Although both drugs are anxiolytics, they have many differences. So, Phenibut belongs to the nootropics. This group of drugs activates metabolic processes in the central nervous system, supports its functioning and protects, preventing the development of diseases of the nervous system.
Nootropics have different focuses. The main task of Phenibut is to maintain the Nervous system against the background of severe stress.
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And the instructions for use of Phenazepam state that Phenazepam is a tranquilizer that suppresses the central nervous system. Moreover, the effectiveness of the drug is very high. Of all psychotropic drugs, Phenazepam is considered the most powerful. When administered internally, the drug has an effect similar to that of antipsychotics.
Thus, Phenazepam differs from Phenibut in that it is a powerful sleeping pill, an overdose of which causes symptoms similar to the use of narcotic drugs. And Phenibut has a sedative effect.
Also, Phenibut almost does not cause addiction, and even short-term use of Phenazepam forms a strong addiction. Therefore, the first drug can be purchased without a prescription, and the second only for medical prescription.
The difference between the drugs lies in the contraindications. Thus, taking Phenazepam is prohibited in the following cases:
Source: https://kemvaleo.ru/medicamenty/fenzitat-analogi.html
Comparison of side effects of Phenazepam and Oxazepam
Side effects or adverse events are any adverse medical event that occurs in a subject after administration of a drug.
Phenazepam has more adverse effects than Oxazepam. This implies that the frequency of their occurrence is low with Phenazepam and low with Oxazepam. Frequency of manifestation is an indicator of how many cases of an undesirable effect from treatment are possible and registered. The undesirable effect on the body, the strength of influence and the toxic effect of drugs are different: how quickly the body recovers after taking it and whether it recovers at all. When using Phenazepam, the body's ability to recover faster is higher than that of Oxazepam.
About Phenazepam
The medicine is a highly effective tranquilizer, which has an advantage over its analogues - a complex effect on the body as a whole.
Indications for use
- insomnia, sleep disorder
- unreasonable feelings of fear, anxiety and restlessness
- panic attacks
- seizures, nervous tics
- post-traumatic shock
- neuroses, psychoses
- depression
- emotional instability
- attacks of aggression
- epileptic seizures
Comparison of ease of use of Phenazepam and Oxazepam
This includes dose selection taking into account various conditions and frequency of doses. At the same time, it is important not to forget about the release form of the drug; it is also important to take it into account when making an assessment.
The ease of use of Phenazepam is approximately the same as Oxazepam. However, they are not convenient enough to use.
The drug ratings were compiled by experienced pharmacists who studied international research. The report is generated automatically.
Last update date: 2020-12-13 10:31:30
